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WAO Guideline for the Management of Hereditary Angioedema

Timothy Craig1, Emel Aygören Pürsün2, Konrad Bork3, Tom Bowen4, Henrik Boysen5, Henriette Farkas6, Anete Grumach7, Constance H Katelaris8, Richard Lockey9, Hilary Longhurst10, William Lumry11, Markus Magerl12, Immaculada Martinez-Saguer2, Bruce Ritchie13, Alexander Nast12, Ruby Pawankar14, Bruce Zuraw15 and Marcus Maurer12*

Author Affiliations

1 Department of Medicine, Pediatrics and Graduate Studies, Penn State University, Hershey, PA

2 Center for Pediatric and Juvenile Medicine, J.W. Goethe University, Frankfurt/(Main), Germany

3 Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany

4 Departments of Medicine and Pediatrics, University of Calgary, Calgary, Canada

5 HAEi, Orsay, France

6 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

7 Outpatient Group of Recurrent Infections and Laboratory of Immunology, Faculty of Medicine ABC; Department of Dermatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil

8 Department of Medicine, Campbelltown Hospital, University of Western Sydney, Sydney, New South Wales, Australia

9 Allergy, Asthma and Immunology Associates of Tampa Bay, University of South Florida, Tampa, FL

10 Department of Immunology, Barts Health NHS Trust, London, United Kingdom

11 Allergy and Asthma Specialists, Dallas, TX

12 Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany

13 Department of Medicine, University of Alberta, Edmonton, Canada

14 Division of Allergy, Dept. of Pediatrics, Nippon Medical School, Tokyo, Japan

15 President WAO, Professor of Medicine, Department of Medicine, University of California San Diego and San Diego VA Healthcare

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World Allergy Organization Journal 2012, 5:182-199  doi:10.1097/WOX.0b013e318279affa

Published: 15 December 2012


Hereditary Angioedema (HAE) is a rare disease and for this reason proper diagnosis and appropriate therapy are often unknown or not available for physicians and other health care providers. For this reason we convened a group of specialists that focus upon HAE from around the world to develop not only a consensus on diagnosis and management of HAE, but to also provide evidence based grades, strength of evidence and classification for the consensus. Since both consensus and evidence grading were adhered to the document meets criteria as a guideline. The outcome of the guideline is to improve diagnosis and management of patients with HAE throughout the world and to help initiate uniform care and availability of therapies to all with the diagnosis no matter where the residence of the individual with HAE exists.

Hereditary Angioedema; Guidelines; HAE; therapy; management; diagnosis; medications; international