Open Access Open Badges Case Report

Oral vancomycin desensitisation to treat Clostridium difficile infection in a vancomycin allergic patient

Shanti Mahabir1*, Ren Yik Lim2, Fidelma Fitzpatrick34, Colm Magee2 and Mary Keogan1

Author Affiliations

1 Immunology Department, Beaumont Hospital, Dublin 9, Ireland

2 Department of Renal Medicine, Beaumont Hospital, Dublin 9, Ireland

3 Microbiology Department, Beaumont Hospital, Dublin, Ireland

4 Health Protection Surveillance Centre, Dublin, Ireland

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World Allergy Organization Journal 2013, 6:16  doi:10.1186/1939-4551-6-16

Published: 30 September 2013


The prevalence of Clostridium difficile infection (CDI) is increasing worldwide. Oral vancomycin is an effective and frequently used treatment. However, patients with CDI who are allergic to intravenous vancomycin cannot receive oral vancomycin due to the risk of anaphylaxis if given the oral form.

We present a case where oral vancomycin desensitisation was used to successfully treat a vancomycin allergic patient with recurrent CDI.

Allergy; Anaphylaxis; Desensitisation; Vancomycin; Clostridium difficile