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Open Access Highly Accessed Case Report

Aquagenic urticaria in twins

Anneke C Kai1* and Carsten Flohr12

Author Affiliations

1 Cutaneous Allergy Department, St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation Trust, Westminster Bridge Road, SE1 7EH, London, UK

2 King’s College London, Strand, WC2R 2LS, London, UK

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World Allergy Organization Journal 2013, 6:2  doi:10.1186/1939-4551-6-2

Published: 31 January 2013


We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. This rare form of urticaria usually presents within an hour of contact with water. The aetiology is unknown. Most cases are sporadic but there are a small number of familial cases in the medical literature. A specific genetic mutation has not yet been found. To our knowledge, this is the first report of aquagenic urticaria in monozygotic twins, further supporting a genetic component to this disease.

Urticaria; Aquagenic