Aquagenic urticaria in twins
1 Cutaneous Allergy Department, St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation Trust, Westminster Bridge Road, SE1 7EH, London, UK
2 King’s College London, Strand, WC2R 2LS, London, UK
World Allergy Organization Journal 2013, 6:2 doi:10.1186/1939-4551-6-2Published: 31 January 2013
We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. This rare form of urticaria usually presents within an hour of contact with water. The aetiology is unknown. Most cases are sporadic but there are a small number of familial cases in the medical literature. A specific genetic mutation has not yet been found. To our knowledge, this is the first report of aquagenic urticaria in monozygotic twins, further supporting a genetic component to this disease.